This paper discusses the major hazardous activities during the casing and cementing operation with potential associated hazards in the on and offshore oil and gas industries of Malaysia, Pakistan and Saudi Arabia. The researcher adopted the explanatory research approach for the quantitative (survey questionnaire) and qualitative research methods (semi-structured interview) in the data collection process. Eighty drilling crew were randomly selected for quantitative research, while three safety officers were purposively selected for qualitative research from each targeted industry. According to the findings of this study, running casing to wells and circulation cementing activity is considered highly hazardous at the offshore site. At the Saudi Arabian onshore domain, running casing to holes is more hazardous, while at offshore domains, installation of casing and casing accessories is more hazardous than in Malaysia and Pakistan. The participants from the Pakistani offshore industry reported that installation of casing and circulation of cementing activity were highly hazardous. In the context of overall casing and cementing operation among the focus industries, the Malaysian on and offshore oil and gas industry considers the casing and cementing operation as more hazardous compared to that of other industries, with a total mean range of 3.37 for onshore and 3.45 for offshore sites that lie under a moderate level of the mean range. The dangers are associated with potential ergonomic, chemical and safety hazards during on and offshore operation.